Coinfections identified from metagenomic analysis of cervical lymph nodes from tularemia patients.

ABSTRACT:

Background

Underlying coinfections may complicate infectious disease states but commonly go unnoticed because an a priori clinical suspicion is usually required so they can be detected via targeted diagnostic tools. Shotgun metagenomics is a broad diagnostic tool that can be useful for identifying multiple microbes simultaneously especially if coupled with lymph node aspirates, a clinical matrix known to house disparate pathogens. The objective of this study was to analyze the utility of this unconventional diagnostic approach (shotgun metagenomics) using clinical samples from human tularemia cases as a test model. Tularemia, caused by the bacterium Francisella tularensis, is an emerging infectious disease in Turkey. This disease commonly manifests as swelling of the lymph nodes ne

SUBMITTER: Birdsell DN 

PROVIDER: S-EPMC6042416 | biostudies-literature | 2018 Jul

REPOSITORIES: biostudies-literature