Chlamydia and Lipids Engage a Common Signaling Pathway That Promotes Atherogenesis.

ABSTRACT:

Background

Recent studies indicate that Toll-like receptor 4 (TLR4) and myeloid differentiation factor 88 (MyD88) signaling promote the development of high fat diet-induced atherosclerosis in hypercholesterolemic mice.

Objectives

The authors investigated the role of TLR4/MyD88 signaling in hematopoietic and stromal cells in the development and infection-mediated acceleration of atherosclerosis.

Methods

The authors generated bone marrow chimeras between wild-type and Tlr4^-/- mice, as well as wild-type and Myd88^-/- mice. All mice were on the Apoe^-/- background and fed high fat diet. The authors infected the chimeric mice with C. pneumoniae (CP) and fed them high fat diet.

Results

Aortic sinus plaques and lipid content were signifi

SUBMITTER: Chen S 

PROVIDER: S-EPMC6042865 | biostudies-literature | 2018 Apr

REPOSITORIES: biostudies-literature