Progressive lentivirus infection induces natural killer cell receptor-expressing B cells in the gastrointestinal tract.

ABSTRACT:

Objective

Recently, a seemingly novel innate immune cell subset bearing features of natural killer and B cells was identified in mice. So-called NKB cells appear as first responders to infections, but whether this cell population is truly novel or is in fact a subpopulation of B cells and exists in higher primates remains unclear. The objective of this study was to identify NKB cells in primates and study the impact of HIV/SIV infections.

Design and methods

NKB cells were quantified in both naive and lentivirus infected rhesus macaques and humans by excluding lineage markers (CD3, CD127) and positive Boolean gating for CD20, NKG2A/C and/or NKp46. Additional phenotypic measures were conducted by RNA-probe and traditional flow cytometry.

Results

Circulating cytotoxic NK

SUBMITTER: Manickam C 

PROVIDER: S-EPMC6043388 | biostudies-literature | 2018 Jul

REPOSITORIES: biostudies-literature