Molecular characterization and expression of a disintegrin and metalloproteinase with thrombospondin motifs 8 in chicken.

ABSTRACT:

Objective

A disintegrin and metallopeptidase with thrombospondin motifs type 8 (ADAMTS8) is crucial for diverse physiological processes, such as inflammation, tissue morphogenesis, and tumorigenesis. The chicken ADAMTS8 (chADAMTS8) gene was differentially expressed in the kidney following exposure to different calcium concentrations, suggesting a pathological role of this protein in metabolic diseases. We aimed to examine the molecular characteristics of chADAMTS8 and analyze the gene-expression differences in response to toll-like receptor 3 (TLR3) stimulation.

Methods

The ADAMTS8 mRNA and amino acid sequences of various species (chicken, duck, cow, mouse, rat, human, chimpanzee, pig, and horse) were retrieved from the Ensembl database and subjected to bioinformatics analys

SUBMITTER: Lee RH 

PROVIDER: S-EPMC6043438 | biostudies-literature | 2018 Aug

REPOSITORIES: biostudies-literature