Impact of brain-derived neurotrophic factor genetic polymorphism on cognition: A systematic review.

ABSTRACT:

Introduction

Brain-derived neurotrophic factor (BDNF) has an important role in the neurogenesis and neuroplasticity of the brain. This systematic review was designed to examine the association between BDNF Val66Met (rs6265) polymorphism and four cognitive domains-attention and concentration, executive function, verbal fluency, and memory, respectively.

Methodology

Primary literature search was performed using search engines such as PubMed and Scopus. Observational studies that evaluated the neurocognitive performances in relation to BDNF polymorphism within human subjects were included in this review, while animal studies, overlapping studies, and meta-analysis were excluded.

Results

Forty of 82 reviewed studies (48.8%) reported an association between Val66Met polymor

SUBMITTER: Toh YL 

PROVIDER: S-EPMC6043712 | biostudies-literature | 2018 Jul

REPOSITORIES: biostudies-literature