Chandipura Virus Induced Neuronal Apoptosis via Calcium Signaling Mediated Oxidative Stress.

ABSTRACT: Chandipura Virus (CHPV) a negative-stranded RNA virus belonging to the Rhabdoviridae family, has been previously reported to bring about neuronal apoptosis by stimulating oxidative stress. Our in silico data suggested the involvement of Angiotensin II in intracellular Ca²⁺ secretion within CHPV infected cells that further lead to enhancement of ROS level and mitochondrial dysfunction. ROS is also known to phosphorylate p38 that leads to neuronal apoptosis through FasL-FADD pathway during CHPV infection. Minocycline a broad-spectrum antibiotic well-known for its anti-oxidative and anti-inflammatory role was used in the present study to investigate its efficacy against CHPV. The results obtained from the present study showed minocycline to be effective in mitigating

SUBMITTER: Verma AK 

PROVIDER: S-EPMC6043780 | biostudies-literature | 2018

REPOSITORIES: biostudies-literature