Master Regulators Connectivity Map: A Transcription Factors-Centered Approach to Drug Repositioning.

ABSTRACT: Drug discovery is a very expensive and time-consuming endeavor. Fortunately, recent omics technologies and Systems Biology approaches introduced interesting new tools to achieve this task, facilitating the repurposing of already known drugs to new therapeutic assignments using gene expression data and bioinformatics. The inherent role of transcription factors in gene expression modulation makes them strong candidates for master regulators of phenotypic transitions. However, transcription factors expression itself usually does not reflect its activity changes due to post-transcriptional modifications and other complications. In this aspect, the use of high-throughput transcriptomic data may be employed to infer transcription factors-targets interactions and assess their activity through co-

SUBMITTER: De Bastiani MA 

PROVIDER: S-EPMC6043797 | biostudies-literature | 2018

REPOSITORIES: biostudies-literature