A pilot study to profile salivary angiogenic factors to detect head and neck cancers.

ABSTRACT:

Background

Early diagnosis of head and neck squamous cell carcinoma (HNSCCs) is an appealing way to increase survival rates in these patients as well as to improve quality of life post-surgery. Angiogenesis is a hallmark of tumor initiation and progression. We have investigated a panel of angiogenic factors in saliva samples collected from HNSCC patients and controls using the Bio-Plex ProT^M assays.

Methods

We have identified a panel of five angiogenic proteins (sEGFR, HGF, sHER2, sIL-6Ra and PECAM-1) to be elevated in the saliva samples collected from HNSCC patients (n = 58) compared to a control cohort (n = 8 smokers and n = 30 non-smokers).

Results

High positive correlations were observed between the following sets of salivary proteins; sEGFR:sHER2, sEGF

SUBMITTER: van der Merwe L 

PROVIDER: S-EPMC6043960 | biostudies-literature | 2018 Jul

REPOSITORIES: biostudies-literature