Pharmacokinetics of lotilaner following a single oral or intravenous administration in cats.

ABSTRACT:

Background

Credelio^TM (lotilaner) is an oral ectoparasiticide from the isoxazoline class developed for the treatment of flea and tick infestations in cats. It is formulated as a pure S-enantiomer in flavoured chewable tablets. The pharmacokinetics of lotilaner were investigated after intravenous or oral administration and under fed or fasted conditions in cats. Twenty-six adult cats were enrolled in a pharmacokinetic study evaluating either intravenous or oral administration of lotilaner. Following the oral administration at a dosage of 6 mg/kg, under fed or fasted conditions, or intravenous administration of 3 mg/kg, blood samples were collected up to 35 days after treatment. Lotilaner blood concentrations were measured using a validated liquid chromatography/tandem mas

SUBMITTER: Toutain CE 

PROVIDER: S-EPMC6044034 | biostudies-literature | 2018 Jul

REPOSITORIES: biostudies-literature