Exosomes from acellular Wharton's jelly of the human umbilical cord promotes skin wound healing.

ABSTRACT:

Background

Compromised wound healing has become a global public health challenge which presents a significant psychological, financial, and emotional burden on patients and physicians. We recently reported that acellular gelatinous Wharton's jelly of the human umbilical cord enhances skin wound healing in vitro and in vivo in a murine model; however, the key player in the jelly which enhances wound healing is still unknown.

Methods

We performed mass spectrometry on acellular gelatinous Wharton's jelly to elucidate the chemical structures of the molecules. Using an ultracentrifugation protocol, we isolated exosomes and treated fibroblasts with these exosomes to assess their proliferation and migration. Mice were subjected to a full-thickness skin biopsy experiment and treated

SUBMITTER: Bakhtyar N 

PROVIDER: S-EPMC6044104 | biostudies-literature | 2018 Jul

REPOSITORIES: biostudies-literature