Immune function after major surgical interventions: the effect of postoperative pain treatment.

ABSTRACT:

Introduction

Impaired immune function during the perioperative period may be associated with worse short- and long-term outcomes. Morphine is considered a major contributor to immune modulation.

Patients and methods

We performed a pilot study to investigate postoperative immune function by analyzing peripheral blood mononuclear cells' functionality and cytokine production in 16 patients undergoing major abdominal surgery. All patients were treated with intravenous (i.v.) patient-controlled analgesia with morphine and continuous wound infusion with ropivacaine+methylprednisolone for 24 hours. After 24 hours, patients were randomized into two groups, one continuing intrawound infusion and the other receiving only i.v. analgesia. We evaluated lymphoproliferation and cytokine pr

SUBMITTER: Amodeo G 

PROVIDER: S-EPMC6044362 | biostudies-literature | 2018

REPOSITORIES: biostudies-literature