Effect of Oral Voriconazole on Fungal Keratitis in the Mycotic Ulcer Treatment Trial II (MUTT II): A Randomized Clinical Trial.

ABSTRACT:

Objective

To compare oral voriconazole with placebo in addition to topical antifungals in the treatment of filamentous fungal keratitis.

Design, setting, and participants

The Mycotic Ulcer Treatment Trial II (MUTT II), a multicenter, double-masked, placebo-controlled, randomized clinical trial, was conducted in India and Nepal, with 2133 individuals screened for inclusion. Patients with smear-positive filamentous fungal ulcers and visual acuity of 20/400 (logMAR 1.3) or worse were randomized to receive oral voriconazole vs oral placebo; all participants received topical antifungal eyedrops. The study was conducted from May 24, 2010, to November 23, 2015. All trial end points were analyzed on an intent-to-treat basis.

Interventions

Study participants were randomized to

SUBMITTER: Prajna NV 

PROVIDER: S-EPMC6044431 | biostudies-literature | 2016 Dec

REPOSITORIES: biostudies-literature