Induction of innate immune memory via microRNA targeting of chromatin remodelling factors.

ABSTRACT: Prolonged exposure to microbial products such as lipopolysaccharide can induce a form of innate immune memory that blunts subsequent responses to unrelated pathogens, known as lipopolysaccharide tolerance. Sepsis is a dysregulated systemic immune response to disseminated infection that has a high mortality rate. In some patients, sepsis results in a period of immunosuppression (known as 'immunoparalysis')¹ characterized by reduced inflammatory cytokine output², increased secondary infection³ and an increased risk of organ failure and mortality⁴. Lipopolysaccharide tolerance recapitulates several key features of sepsis-associated immunosuppression⁵. Although various epigenetic changes have previously been observed in tolerized macrophag

SUBMITTER: Seeley JJ 

PROVIDER: S-EPMC6044474 | biostudies-literature | 2018 Jul

REPOSITORIES: biostudies-literature