Biological Thiols and Carbon Disulfide: The Formation and Decay of Trithiocarbonates under Physiologically Relevant Conditions.

ABSTRACT: Carbon disulfide is an environmental toxin, but there are suggestions in the literature that it may also have regulatory and/or therapeutic roles in mammalian physiology. Thiols or thiolates would be likely biological targets for an electrophile, such as CS₂, and in this context, the present study examines the dynamics of CS₂ reactions with various thiols (RSH) in physiologically relevant near-neutral aqueous media to form the respective trithiocarbonate anions (TTC^-, also known as "thioxanthate anions"). The rates of TTC^- formation are markedly pH-dependent, indicating that the reactive form of RSH is the conjugate base RS^-. The rates of the reverse reaction, that is, decay of TTC^- anions to release CS₂, is pH-in

SUBMITTER: Souza ML 

PROVIDER: S-EPMC6044626 | biostudies-literature | 2017 Oct

REPOSITORIES: biostudies-literature