Macrophage-Mediated Effects of Airborne Fine Particulate Matter (PM_2.5) on Hepatocyte Insulin Resistance in Vitro.

ABSTRACT: Fine particulate matter (PM_2.5) pollution poses significant health risks worldwide, including metabolic syndrome-related diseases with the characteristic feature of insulin resistance. However, the mechanism and influencing factors of this effect are poorly understood. In this serial in vitro study, we aimed at testing the hypothesis that macrophage-mediated effects of PM_2.5 on hepatic insulin resistance depend on its chemical composition. Mouse macrophages were exposed to PM_2.5 that had been collected during summer or winter in Beijing, which represented different compositions of PM_2.5. Thereafter, hepatocytes were treated with macrophage-conditioned medium (CM). PM_2.5 induced interleukin-6, tumor necrosis factor-α, and monocyte chemo

SUBMITTER: Li R 

PROVIDER: S-EPMC6044713 | biostudies-literature | 2016 Nov

REPOSITORIES: biostudies-literature