EDB Fibronectin-Specific SPECT Probe ^99mTc-HYNIC-ZD2 for Breast Cancer Detection.

ABSTRACT: Extradomain-B fibronectin (EDB-FN), an oncofetal isoform of FN, is a promising diagnostic and therapeutic target of tumors, including breast cancer. Many EDB-FN-targeted drugs have been developed and have shown therapeutic effects in clinical trials. Molecular imaging to visualize EDB-FN-positive cancers may help select the right patients who will be benefit from EDB-FN-targeted therapy. Although a few EDB-FN-targeted imaging probes have been developed, the complicated manufacturing procedure and expensive material and equipment required limit their application for large-scale screening of EDB-FN-positive cancer patients. Thus, more simple and economic EDB-FN-targeted imaging probes are still urgently needed. Previously, we have identified a breast cancer-targeted peptide, CTVRTSADC. Coinc

SUBMITTER: Ye XX 

PROVIDER: S-EPMC6044779 | biostudies-literature | 2017 Jun

REPOSITORIES: biostudies-literature