Influence of Hyperglycemic Conditions on Self-Association of the Alzheimer's Amyloid β (Aβ_1-42) Peptide.

ABSTRACT: Clinical studies have identified a correlation between type-2 diabetes mellitus and cognitive decrements en route to the onset of Alzheimer's disease (AD). Recent studies have established that post-translational modifications of the amyloid β (Aβ) peptide occur under hyperglycemic conditions; particularly, the process of glycation exacerbates its neurotoxicity and accelerates AD progression. In view of the assertion that macromolecular crowding has an altering effect on protein self-assembly, it is crucial to characterize the effects of hyperglycemic conditions via crowding on Aβ self-assembly. Toward this purpose, fully atomistic molecular dynamics simulations were performed to study the effects of glucose crowding on Aβ dimerization, which is the smallest known neurotoxic species. The di

SUBMITTER: Menon S 

PROVIDER: S-EPMC6044820 | biostudies-literature | 2017 May

REPOSITORIES: biostudies-literature