Intracellular Trafficking of Fluorescent Nanodiamonds and Regulation of Their Cellular Toxicity.

ABSTRACT: In this paper, cellular management of fluorescent nanodiamonds (FNDs) has been studied for better understanding in the design for potential applications of FNDs in biomedicine. The FNDs have shown to be photostable probes for bioimaging and thus are well-suited, for example, long-term tracking purposes. The FNDs also exhibit good biocompatibility and, in general, low toxicity for cell labeling. To demonstrate the underlying mechanism of cells coping the low but potentially toxic effects by nondegradable FNDs, we have studied their temporal intracellular trafficking. The FNDs were observed to be localized as distinct populations inside cells in early endosomes, lysosomes, and in proximity to the plasma membrane. The localization of FNDs in early endosomes suggests the internalization of FND

SUBMITTER: Prabhakar N 

PROVIDER: S-EPMC6044821 | biostudies-literature | 2017 Jun

REPOSITORIES: biostudies-literature