Enhancing Passive Transport of Micro/Nano Particles into Cells by Oxidized Carbon Black.

ABSTRACT: Uses of micro-/nano-sized particles to deliver biologically active entities into cells are common for medical therapeutics and prophylactics and also for cellular experiments. Enhancing cellular uptake and avoiding destruction by lysosomes are desirable for general particulate drug delivery systems. Here, we show that the relatively nontoxic, negatively charged oxidized carbon black particles (OCBs) can enhance cellular penetration of micro- and nano-particles. Experiments with retinal-grafted chitosan particles (PRPs) with hydrodynamic sizes of 1200 ± 51.5, 540 ± 29.0, and 430 ± 11.0 nm (three-sized model particles) indicate that only the sub-micron-sized particles can penetrate the first layer of multilayered liposomes. However, in the presence of OCBs, the micron-sized PRPs and the two

SUBMITTER: Amornwachirabodee K 

PROVIDER: S-EPMC6044846 | biostudies-literature | 2018 Jun

REPOSITORIES: biostudies-literature