Fluorescent and Photosensitizing Conjugates of Cell-Penetrating Peptide TAT(47-57): Design, Microwave-Assisted Synthesis at 60 °C, and Properties.

ABSTRACT: Conjugates based on cell-penetrating peptides (CPPs) are scientifically relevant owing to their structural complexity; their ability to enter cells and deliver drugs, labels, antioxidants, bioactive compounds, or DNA fragments; and, consequently, their potential for application in research and biomedicine. In this study, carboxyamidated fluorescently labeled conjugates FAM-GG-TAT(47-57)-NH₂ and FAM-PEG₆-TAT(47-57)-NH₂ and photosensitizer-labeled conjugate Ch_k-PEG₆-TAT(47-57)-NH₂ [where TAT(47-57) is the CPP, 5(6)-carboxyfluorescein is the (FAM) fluorophore, chlorin k (Ch_k) is the photosensitizer, and the dipeptide glycyl-glycine (GG) or hexaethylene glycol (PEG₆) is the spacer] were originally designed,

SUBMITTER: Okuda-Shinagawa NM 

PROVIDER: S-EPMC6044864 | biostudies-literature | 2017 Nov

REPOSITORIES: biostudies-literature