PH-Responsive Charge-Conversional and Hemolytic Activities of Magnetic Nanocomposite Particles for Cell-Targeted Hyperthermia.

ABSTRACT: Magnetic nanocomposite particle (MNP)-induced hyperthermia therapy has been restricted by inefficient cellular targeting. pH-responsive charge-conversional MNPs can enhance selective cellular uptake in acidic cells like tumors by sensing extracellular acidity based on their charge alteration. We have synthesized new, pH-induced charge-conversional, superparamagnetic, and single-cored Fe₃O₄ nanocomposite particles coated by N-itaconylated chitosan (NICS) cross-linked with ethylene glycol diglycidyl ether (EGDE) (Fe₃O₄-NICS-EGDE) using a simple, one-step chemical coprecipitation-coating process. The surface of the Fe₃O₄-NICS-EGDE nanocomposite particles was modified with ethanolamine (EA) via aza-Michael addition to enh

SUBMITTER: Rahman MA 

PROVIDER: S-EPMC6045334 | biostudies-literature | 2018 Jan

REPOSITORIES: biostudies-literature