Phytochemicals as Dynamic Surface Ligands To Control Nanoparticle-Protein Interactions.

ABSTRACT: The rapid formation of the protein corona on to the nanoparticle (NP) surface is the key that confers biological identity to NPs and subsequently dictates their fate both in vitro and in vivo. Despite significant efforts, the inability to control the spontaneous interaction of serum proteins with the administered NPs remains a major constraint in clinical translation of nanomedicines. The ligands present on the NP surface offer promise in controlling their biological interactions; however, their influence on the NP-protein interaction is not well-understood. The current study investigates the potential of phytochemical-capped silver nanoparticles (AgNPs) toward allowing a control over NP interactions with the human serum albumin (HSA), the most abundant protein in the biological fluids. Sp

SUBMITTER: Abraham AN 

PROVIDER: S-EPMC6045335 | biostudies-literature | 2018 Feb

REPOSITORIES: biostudies-literature