Retrievable hydrogels for ovarian follicle transplantation and oocyte collection.

ABSTRACT: Cancer survivorship rates have drastically increased due to improved efficacy of oncologic treatments. Consequently, clinical concerns have shifted from solely focusing on survival to quality of life, with fertility preservation as an important consideration. Among fertility preservation strategies for female patients, ovarian tissue cryopreservation and subsequent reimplantation has been the only clinical option available to cancer survivors with cryopreserved tissue. However, follicle atresia after transplantation and risk of reintroducing malignant cells have prevented this procedure from becoming widely adopted in clinics. Herein, we investigated the encapsulation of ovarian follicles in alginate hydrogels that isolate the graft from the host, yet allows for maturation after transplant

SUBMITTER: Rios PD 

PROVIDER: S-EPMC6045426 | biostudies-literature | 2018 Aug

REPOSITORIES: biostudies-literature