Blue Light Enhances Bacterial Clearance and Reduces Organ Injury During Sepsis.

ABSTRACT: OBJECTIVES:The physiology of nearly all mammalian organisms are entrained by light and exhibit circadian rhythm. The data derived from animal studies show that light influences immunity, and these neurophysiologic pathways are maximally entrained by the blue spectrum. Here, we hypothesize that bright blue light reduces acute kidney injury by comparison with either bright red or standard, white fluorescent light in mice subjected to sepsis. To further translational relevance, we performed a pilot clinical trial of blue light therapy in human subjects with appendicitis. DESIGN:Laboratory animal research, pilot human feasibility trial. SETTING:University basic science laboratory and tertiary care hospital. SUBJECTS:Male C57BL/6J mice, adult (> 17 yr) patients with acute appendicitis. INTERVEN

SUBMITTER: Lewis AJ 

PROVIDER: S-EPMC6045458 | biostudies-literature | 2018 Aug

REPOSITORIES: biostudies-literature