Targeting of a Photosensitizer to the Mitochondrion Enhances the Potency of Photodynamic Therapy.

ABSTRACT: Photodynamic therapy (PDT) involves use of a photosensitizer, whose activation with light leads to the production of singlet oxygen (SOS), generation of reactive oxygen species (ROS), and initiation of associated cell toxicity. Because a cell's mitochondria constitute sites where oxygen levels are high, ROS can be readily produced, and apoptosis is commonly initiated. Therefore, an ideal PDT agent might be a potent photosensitizer that could naturally accumulate in mitochondria. Although a number of mitochondria-targeting moieties, including triphenylphosphine, guanidinium, and bisguanidium, have been identified, a quantitative comparison of their efficacies in targeting mitochondria has not been performed. In this study, we have prepared triphenylphosphine, guanidinium, and bisguanidium d

SUBMITTER: Mahalingam SM 

PROVIDER: S-EPMC6045488 | biostudies-literature | 2018 Jun

REPOSITORIES: biostudies-literature