Feasibility of serum CGRP measurement as a biomarker of chronic migraine: a critical reappraisal.

ABSTRACT:

Background

Calcitonin gene-related peptide (CGRP) has been reported as elevated in chronic migraine. We aimed to validate the role of interictal serum CGRP concentration in peripheral blood samples as a biomarker of chronic migraine.

Methods

We prospectively recruited patients with episodic and chronic migraine and normal controls (NCs) in the Samsung Medical Center between August 2015 and May 2016. Blood samples were collected interictally from antecubital veins per prespecified protocol. Serum CGRP measurement was performed in the central laboratory by a single experienced technician blinded to clinical information. Migraine subtype, headache days in the previous month, and the presence and characteristics of headache at ±2 days of measurement were evaluated at every visit

SUBMITTER: Lee MJ 

PROVIDER: S-EPMC6045522 | biostudies-literature | 2018 Jul

REPOSITORIES: biostudies-literature