Multi-centre evaluation of recent troponin assays for the diagnosis of NSTEMI.

ABSTRACT:

Objectives

We aimed to compare the use of nine different cardiac troponin (cTn) assays (2 cTnT and 7 cTnI) for the diagnosis of NSTEMI in a single multi-centre population.

Design and methods

One hundred and fifty-eight patients were included (mean age 60 years, SD 17 years), including 23 patients (14%) with NSTEMI.

Results

The analytical comparison highlighted a large heterogeneity of cTn assays, as reflected by percentages of patients with detectable cTn, correlation coefficients, Passing-Bablok comparisons and concordance coefficients. Correlations within cTnI assays were good and correlation within cTnT assays was excellent. Diagnostic performances demonstrated that each cTn assay has specific threshold values. Furthermore, some assays (HS-cTnI and T, cTnI-Pathfast

SUBMITTER: Chenevier-Gobeaux C 

PROVIDER: S-EPMC6045566 | biostudies-literature | 2018 Jul

REPOSITORIES: biostudies-literature