Neonatal anesthesia exposure impacts brain microRNAs and their associated neurodevelopmental processes.

ABSTRACT: MicroRNAs (miRNAs), when subjected to environmental stimuli, can exhibit differential expression. As critical regulators of gene expression, differential miRNA expression has been implicated in numerous disorders of the nervous system. In this study, we focused on the effect of a general anesthetic, as an environmental stimulus, on miRNA expression of the developing brain. General anesthetics have potential long-lasting neurotoxic effects on the developing brain, resulting in behavioral changes in adulthood. We first carried out an unbiased profiling approach to examine the effect of single-episode neonatal general anesthetic, sevoflurance (sevo), exposure on miRNA expression of the brain. Neonatal sevo has a significant effect on the expression of specific miRNAs of the whole brain and th

SUBMITTER: Lin D 

PROVIDER: S-EPMC6045579 | biostudies-literature | 2018 Jul

REPOSITORIES: biostudies-literature