In vivo imaging of inflammation and oxidative stress in a nonhuman primate model of cardiac sympathetic neurodegeneration.

ABSTRACT: Loss of cardiac postganglionic sympathetic innervation is a characteristic pathology of Parkinson's disease (PD). It progresses over time independently of motor symptoms and is not responsive to typical anti-parkinsonian therapies. Cardiac sympathetic neurodegeneration can be mimicked in animals using systemic dosing of the neurotoxin 6-hydroxydopamine (6-OHDA). As in PD, 6-OHDA-induced neuronal loss is associated with increased inflammation and oxidative stress. To assess the feasibility of detecting changes over time in cardiac catecholaminergic innervation, inflammation, and oxidative stress, myocardial positron emission tomography with the radioligands [¹¹C]meta-hydroxyephedrine (MHED), [¹¹C]PBR28 (PBR28), and [⁶¹Cu]diacetyl-bis(N(4

SUBMITTER: Metzger JM 

PROVIDER: S-EPMC6045637 | biostudies-literature | 2018

REPOSITORIES: biostudies-literature