Multidrug-resistant Citrobacter freundii ST139 co-producing NDM-1 and CMY-152 from China.

ABSTRACT: The emergence of carbapenemase-producing Citrobacter freundii poses a significant threat to public health worldwide. Here, we reported a C. freundii strain CWH001 which was resistant to all tested antimicrobials except tetracycline. Whole genome sequencing and analysis were performed. The strain, which belonged to a new sequence type ST139, showed close relationship with other foreign C. freundii strains through phylogenetic analysis. A novel variant of the intrinsic bla_CMY gene located on the chromosome was identified and designated as bla_CMY-152. Coexistence of bla_NDM-1 with qnrS1 was found on a conjugative IncN plasmid, which had a backbone appearing in various plasmids. Other class A ESBL genes (bla_VEB-3 and bla_TEM-1) were also det

SUBMITTER: Yang L 

PROVIDER: S-EPMC6045649 | biostudies-literature | 2018 Jul

REPOSITORIES: biostudies-literature