Air Pollution Exposure Is Associated With Lower Lung Function, but Not Changes in Lung Function, in Patients With Idiopathic Pulmonary Fibrosis.

ABSTRACT:

Background

Air pollution exposure is associated with acute exacerbation, disease progression, and mortality in patients with idiopathic pulmonary fibrosis (IPF). The objective of this study was to describe the impact of air pollution exposures on disease severity, as well as changes in lung function, in patients with IPF.

Methods

Using home spirometers and symptom diaries, 25 patients with IPF prospectively recorded FVC weekly for up to 40 weeks. Residential addresses were geocoded to estimate weekly mean air pollution exposures for ground-level ozone (O₃), nitrogen dioxide (NO₂), and particulate matter < 2.5 or 10 μm in aerodynamic diameter (PM_2.5 and PM₁₀, respectively). The dependence of weekly clinical measurements on preceding

SUBMITTER: Johannson KA 

PROVIDER: S-EPMC6045778 | biostudies-literature | 2018 Jul

REPOSITORIES: biostudies-literature