Pyruvate carboxylase supports the pulmonary tropism of metastatic breast cancer.

ABSTRACT:

Background

Overcoming systemic dormancy and initiating secondary tumor grow under unique microenvironmental conditions is a major rate-limiting step in metastatic progression. Disseminated tumor cells encounter major changes in nutrient supplies and oxidative stresses compared to the primary tumor and must demonstrate significant metabolic plasticity to adapt to specific metastatic sites. Recent studies suggest that differential utilization of pyruvate sits as a critical node in determining the organotropism of metastatic breast cancer. Pyruvate carboxylase (PC) is key enzyme that converts pyruvate into oxaloacetate for utilization in gluconeogenesis and replenishment of the TCA cycle.

Methods

Patient survival was analyzed with respect to gene copy number alterations and dif

SUBMITTER: Shinde A 

PROVIDER: S-EPMC6045837 | biostudies-literature | 2018 Jul

REPOSITORIES: biostudies-literature