Recurrent tumor-specific regulation of alternative polyadenylation of cancer-related genes.

ABSTRACT:

Background

Alternative polyadenylation (APA) results in messenger RNA molecules with different 3' untranslated regions (3' UTRs), affecting the molecules' stability, localization, and translation. APA is pervasive and implicated in cancer. Earlier reports on APA focused on 3' UTR length modifications and commonly characterized APA events as 3' UTR shortening or lengthening. However, such characterization oversimplifies the processing of 3' ends of transcripts and fails to adequately describe the various scenarios we observe.

Results

We built a cloud-based targeted de novo transcript assembly and analysis pipeline that incorporates our previously developed cleavage site prediction tool, KLEAT. We applied this pipeline to elucidate the APA profiles of 114 genes in 9939 tumor a

SUBMITTER: Xue Z 

PROVIDER: S-EPMC6045855 | biostudies-literature | 2018 Jul

REPOSITORIES: biostudies-literature