Refining a steroidogenic model: an analysis of RNA-seq datasets from insect prothoracic glands.

ABSTRACT:

Background

The prothoracic gland (PG), the principal steroidogenic organ of insects, has been proposed as a model for steroid hormone biosynthesis and regulation.

Results

To validate the robustness of the model, we present an analysis of accumulated transcriptomic data from PGs of two model species, Drosophila melanogaster and Bombyx mori. We identify that the common core components of the model in both species are encoded by nine genes. Five of these are Halloween genes whose expression differs substantially between the PGs of these species.

Conclusions

We conclude that the PGs can be a model for steroid hormone synthesis and regulation within the context of mitochondrial cholesterol transport and steroid biosynthesis but beyond these core mechanisms, gene expression

SUBMITTER: Moulos P 

PROVIDER: S-EPMC6045881 | biostudies-literature | 2018 Jul

REPOSITORIES: biostudies-literature