Characterization of T cell activation and regulation in children with asymptomatic Plasmodium falciparum infection.

ABSTRACT:

Background

Asymptomatic Plasmodium infections are characterized by the absence of clinical disease and the ability to restrict parasite replication. Increasing levels of regulatory T cells (Tregs) in Plasmodium falciparum infections have been associated with the risk of developing clinical disease, suggesting that individuals with asymptomatic infections may have reduced Treg frequency. However, the relationship between Tregs, cellular activation and parasite control in asymptomatic malaria remains unclear.

Methods

In a cross-sectional study, the levels of Tregs and other T cell activation phenotypes were compared using flow cytometry in symptomatic, asymptomatic and uninfected children before and after stimulation with infected red blood cell lysates (iRBCs). In addition, t

SUBMITTER: Frimpong A 

PROVIDER: S-EPMC6045887 | biostudies-literature | 2018 Jul

REPOSITORIES: biostudies-literature