Interactions between kappa and mu opioid receptor agonists: effects of the ratio of drugs in mixtures.

ABSTRACT:

Rationale

Pain is the leading reason for seeking health care, and mu opioid receptor agonists continue to be prescribed despite well-documented adverse effects. Kappa opioid receptor agonists have antinociceptive effects with little to no abuse liability and might be useful for treating pain in mixtures. Kappa:mu opioid mixtures might be useful if therapeutic effects of each drug can be selectively increased while reducing or avoiding the adverse effects that occur with larger doses of each drug alone.

Objective

This study characterized the effects of the kappa opioid receptor agonist spiradoline alone (0.32-56 mg/kg) and in 1:10, 1:3, 1:1, and 3:1 mixtures with the mu opioid receptor agonists morphine (1.0-32 mg/kg) and etorphine (1-10 μg/kg) on warm water tail-withdrawal l

SUBMITTER: Minervini V 

PROVIDER: S-EPMC6045970 | biostudies-literature | 2018 Aug

REPOSITORIES: biostudies-literature