Genomic Characterization of MDR Escherichia coli Harboring bla_OXA-48 on the IncL/M-type Plasmid Isolated from Blood Stream Infection.

ABSTRACT: Escherichia coli is responsible for a wide variety of community and hospital acquired extraintestinal infections, and the emergence of ESBL resistant isolates is a major clinical concern. In this study, we characterized the genomic attributes of an OXA-48 and CTX-M-3 producing E. coli EC-IMP153. Whole-genome initial assembly produced 146 contigs with a combined 5,504,170 bp in size and a G+C content of 50.5%. wgSNPs-based phylogenetic comparison with 36 publically available genomes was also performed. Comprehensive genomic analysis showed that EC-IMP153 belonged to sequence type ST-405 and harbored several resistance determinants including the β-lactam resistance genes bla_OXA-48, bla_CTX-M-3, bla_TEM-1B, bla

SUBMITTER: Alousi S 

PROVIDER: S-EPMC6046176 | biostudies-literature | 2018

REPOSITORIES: biostudies-literature