The p38 MAPK Inhibitor SB203580 Abrogates Tumor Necrosis Factor-Induced Proliferative Expansion of Mouse CD4⁺Foxp3⁺ Regulatory T Cells.

ABSTRACT: There is now compelling evidence that tumor necrosis factor (TNF) preferentially activates and expands CD4⁺Foxp3⁺ regulatory T cells (Tregs) through TNF receptor type II (TNFR2). However, it remains unclear which signaling transduction pathway(s) of TNFR2 is required for the stimulation of Tregs. Previously, it was shown that the interaction of TNF-TNFR2 resulted in the activation of a number of signaling pathways, including p38 MAPK, NF-κB, in T cells. We thus examined the role of p38 MAPK and NF-κB in TNF-mediated activation of Tregs, by using specific small molecule inhibitors. The results show that treatment with specific p38 MAPK inhibitor SB203580, rather than NF-κB inhibitors (Sulfasalazine and Bay 11-7082), abrogated TNF-induced expansion of Tregs in vitro<

SUBMITTER: He T 

PROVIDER: S-EPMC6046375 | biostudies-literature | 2018

REPOSITORIES: biostudies-literature