Population pharmacokinetics of tacrolimus in children with nephrotic syndrome.

ABSTRACT:

Aims

Nephrotic syndrome (NS) is the most common clinical manifestation of glomerular disease in children. Currently, tacrolimus (TAC) is widely used in children with NS. However, pharmacokinetic data in children with nephrotic syndrome is limited. This study was intended to evaluate the population pharmacokinetics (PPK) of TAC in paediatric NS and to optimize dosing regimen.

Methods

Blood samples from NS children treated with TAC were collected and the blood concentrations of TAC were detected using HPLC-MS/MS. A PPK model was developed using NONMEM software. Pharmacogenetic analysis was carried out in the CYP3A5 gene.

Results

The data from 28 children were used for PPK analysis. A one-compartment model and first-order elimination were accorded with the TAC data in pa

SUBMITTER: Hao GX 

PROVIDER: S-EPMC6046506 | biostudies-literature | 2018 Aug

REPOSITORIES: biostudies-literature