Optimization of ZD2 Peptide Targeted Gd(HP-DO3A) for Detection and Risk-Stratification of Prostate Cancer with MRI.

ABSTRACT: The aim of this work is to optimize a peptide targeted macrocyclic MRI contrast agent for detection and risk-stratification of aggressive prostate cancer. The optimized agent was prepared using click chemistry in the presence of CuSO₄ and ascorbate at room temperature. The T₁ and T₂ relaxivities of ZD2-N3-Gd(HP-DO3A) are 5.44 and 7.10 mM^-1 s^-1 at 1.4 T, and 5.53 and 7.81 mM^-1 s^-1 at 7 T, respectively, higher than the previously reported ZD2-Gd(HP-DO3A). The specific tumor enhancement of the agent was investigated in male nude mice bearing aggressive PC3 human prostate cancer xenografts and slow-growing LNCaP tumor xenografts. Contrast enhanced MR images were acquired using a 2D spin-echo sequence and a 3D FLASH se

SUBMITTER: Ayat NR 

PROVIDER: S-EPMC6047029 | biostudies-literature | 2018 Jul

REPOSITORIES: biostudies-literature