Multiplex genomewide association analysis of breast milk fatty acid composition extends the phenotypic association and potential selection of FADS1 variants to arachidonic acid, a critical infant micronutrient.

ABSTRACT:

Background

Breast milk is the sole nutrition source during exclusive breastfeeding, and polyunsaturated fatty acids (FAs) are critical micronutrients in infant physical and cognitive development. There has been no prior genomewide association study of breast milk, hence our objective was to test for genetic association with breast milk FA composition.

Methods

We measured the fractional composition of 26 individual FAs in breast milk samples from three cohorts totalling 1142 Bangladeshi mothers whose infants were genotyped on the Illumina MEGA chip and replicated on a custom Affymetrix 30K SNP array (n=616). Maternal genotypes were imputed using IMPUTE.

Results

After running 33 separate FA fraction phenotypes, we found that SNPs known to be associated with serum FAs in

SUBMITTER: Mychaleckyj JC 

PROVIDER: S-EPMC6047159 | biostudies-literature | 2018 Jul

REPOSITORIES: biostudies-literature