Long-term Air Pollution Exposure, Genome-wide DNA Methylation and Lung Function in the LifeLines Cohort Study.

ABSTRACT:

Background

Long-term air pollution exposure is negatively associated with lung function, yet the mechanisms underlying this association are not fully clear. Differential DNA methylation may explain this association.

Objectives

Our main aim was to study the association between long-term air pollution exposure and DNA methylation.

Methods

We performed a genome-wide methylation study using robust linear regression models in 1,017 subjects from the LifeLines cohort study to analyze the association between exposure to nitrogen dioxide (NO₂) and particulate matter (PM_2.5, fine particulate matter with aerodynamic diameter ≤2.5 μm; PM₁₀, particulate matter with aerodynamic diameter ≤10 μm) and PM_{2.5absorbance}, indicator of elemental

SUBMITTER: de F C Lichtenfels AJ 

PROVIDER: S-EPMC6047358 | biostudies-literature | 2018 Feb

REPOSITORIES: biostudies-literature