Mimicry of a β-Hairpin Turn by a Nonpeptidic Laterally Flexible Foldamer.

ABSTRACT: The design and characterization of a proteomimetic foldamer that displays lateral flexibility endowed by intramolecular bifurcated hydrogen bonds is reported. The MAMBA scaffold, derived from meta-aminomethylbenzoic acid, adopts a serpentine conformation that mimics the side chain projection of all four residues in a β-hairpin turn.

SUBMITTER: Meisel JW 

PROVIDER: S-EPMC6047514 | biostudies-literature | 2018 Jul

REPOSITORIES: biostudies-literature