MFAP2 promotes epithelial-mesenchymal transition in gastric cancer cells by activating TGF-β/SMAD2/3 signaling pathway.

ABSTRACT:

Introduction

Microfibril-associated protein 2 (MFAP2) is an extracellular matrix protein that interacts with fibrillin to modulate the function of microfibrils. MFAP2 has been reported to play a significant role in obesity, diabetes, and osteopenia, and has been shown to be upregulated in head and neck squamous cell carcinoma. However, the molecular function and prognostic value of MFAP2 have never been reported in gastric cancer (GC) or any other tumors.

Methods

The current study investigated the expression patterns, prognostic significance, functional role, and possible mechanisms of MFAP2 in GC.

Results

We demonstrated that MFAP2 was overexpressed in GC tissues, and its overexpression was significantly correlated with poor overall and disease-free survival in patie

SUBMITTER: Wang JK 

PROVIDER: S-EPMC6047603 | biostudies-literature | 2018

REPOSITORIES: biostudies-literature