The relationship of CDK18 expression in breast cancer to clinicopathological parameters and therapeutic response.

ABSTRACT:

Background

Cyclin-Dependent Kinases (CDKs) are established anti-cancer drug targets and a new generation of CDK inhibitors are providing clinical benefits to a sub-set of breast cancer patients. We have recently shown that human CDK18 promotes efficient cellular responses to replication stress. In the current study, we have investigated the clinicopathological and functional significance of CDK18 expression levels in breast cancers.

Results

High CDK18 protein expression was associated with a triple negative and basal-like phenotype (p = 0.021 and 0.027 respectively) as well as improved patient survival, which was particularly significant in ER negative breast cancers (n = 594, Log Rank 6.724, p = 0.01) and those treated with chemotherapy (n = 270,

SUBMITTER: Barone G 

PROVIDER: S-EPMC6047673 | biostudies-literature | 2018 Jun

REPOSITORIES: biostudies-literature