Intracellular Ca²⁺ release decelerates mitochondrial cristae dynamics within the junctions to the endoplasmic reticulum.

ABSTRACT: Mitochondria are multifunctional organelles that essentially contribute to cell signaling by sophisticated mechanisms of communications. Live cell imaging studies showed that mitochondria are dynamic and complex structures that form ramified networks by directed movements, fission, and fusion events. There is emerging evidence that the morphology of mitochondria determines cellular functions and vice versa. Several intracellular signaling pathways and messengers including Ca²⁺ dynamically influence the architecture of mitochondria. Because electron microscopy cannot be utilized for an assessment of dynamics of mitochondrial morphology in intact cells, most studies were performed using wide-field or laser confocal fluorescence microscopies that, due to limitations of their spatia

SUBMITTER: Gottschalk B 

PROVIDER: S-EPMC6047742 | biostudies-literature | 2018 Aug

REPOSITORIES: biostudies-literature