Multiparametric magnetic resonance imaging of experimental chronic kidney disease: A quantitative correlation study with histology.

ABSTRACT:

Objectives

In human chronic kidney disease (CKD) the extent of renal tubulointerstitial fibrosis correlates with progressive loss of renal function. However, fibrosis can so far only be assessed by histology of kidney biopsies. Magnetic resonance imaging (MRI) can provide information about tissue architecture, but its potential to assess fibrosis and inflammation in diseased kidneys remains poorly defined.

Materials and methods

We evaluated excised kidneys in a murine adenine-induced nephropathy model for CKD by MRI and correlated quantitative MRI parameters (T1, T2, and T2* relaxation times, apparent diffusion coefficient and fractional anisotropy) with histological hallmarks of progressive CKD, including renal fibrosis, inflammation, and microvascular rarefaction. Furtherm

SUBMITTER: Schley G 

PROVIDER: S-EPMC6047786 | biostudies-literature | 2018

REPOSITORIES: biostudies-literature