Gene Expression in Parp1 Deficient Mice Exposed to a Median Lethal Dose of Gamma Rays.

ABSTRACT: There is a current interest in the development of biodosimetric methods for rapidly assessing radiation exposure in the wake of a large-scale radiological event. This work was initially focused on determining the exposure dose to an individual using biological indicators. Gene expression signatures show promise for biodosimetric application, but little is known about how these signatures might translate for the assessment of radiological injury in radiosensitive individuals, who comprise a significant proportion of the general population, and who would likely require treatment after exposure to lower doses. Using Parp1^-/- mice as a model radiation-sensitive genotype, we have investigated the effect of this DNA repair deficiency on the gene expression response to radiation. Altho

SUBMITTER: Suresh Kumar MA 

PROVIDER: S-EPMC6047867 | biostudies-literature | 2018 Jul

REPOSITORIES: biostudies-literature