S100A12 as a marker of worse cardiac output and mortality in pulmonary hypertension.

ABSTRACT:

Background and objective

Molecular biomarkers are needed to refine prognostication and phenotyping of pulmonary hypertension (PH) patients. S100A12 is an emerging biomarker of various inflammatory diseases. This study aims to determine the prognostic value of S100A12 in PH.

Methods

Exploratory microarray analysis performed on peripheral blood mononuclear cells (PBMC) collected from idiopathic pulmonary fibrosis (IPF) patients suggested an association between S100A12 and both PH and mortality. So the current study was designed to evaluate for an association between S100A12 in peripheral blood collected from two well-phenotyped PH cohorts in two other centres to derive and validate an association between S100A12 protein serum concentrations and mortality.

Results

The ma

SUBMITTER: Tzouvelekis A 

PROVIDER: S-EPMC6047907 | biostudies-literature | 2018 Aug

REPOSITORIES: biostudies-literature