Does a cognitive stress test predict progression from mild cognitive impairment to dementia equally well in clinical versus population-based settings?

ABSTRACT: ABSTRACTBackground:Evidence suggests that semantic interference may be a sensitive indicator of early dementia. We examined the utility of the Semantic Interference Test (SIT), a cognitive stress memory paradigm which taps proactive and retroactive semantic interference, for predicting progression from mild cognitive impairment (MCI) to dementia in both a clinical and a population-based sample.

Methods

Participants with MCI in the clinical (n = 184) and population-based (n = 435) samples were followed for up to four years. We employed receiver operating characteristic (ROC) methods to establish optimal thresholds for four different SIT indices. Threshold performance was compared in the two samples using logistic and Cox proportional hazard regression models.

Results

Within fo

SUBMITTER: Beer JC 

PROVIDER: S-EPMC6047940 | biostudies-literature | 2018 Oct

REPOSITORIES: biostudies-literature